Skip to main content
Figure 1 | Molecular Neurodegeneration

Figure 1

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

Figure 1

Both rs3846662 and rs1532085 are significantly associated with AD age-of-onset. (A-C) Carriers of the rs3846662_G allele exhibit a significantly earlier onset of AD than AA homozygotes, stratified by the number of APOE-ε4 alleles present. (D-F) Individuals homozygous for the A allele of rs1532085 exhibit a significantly later onset of AD than carriers of the G allele, again stratified by the number of APOE-ε4 alleles present. (A/D - no APOE-ε4, B/E - 1 copy of APOE-ε4, C/F - 2 copies of APOE-ε4)

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326