Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

Table 2 Phase 2 analysis of association between cholesterol SNPs and AD.

The three SNPs from Phase 1 that were either nominally associated or trended with AD (p < 0.1) and are associated with gene regulation were tested for their association with AD in a second case-control population. Both rs3846662 and rs1523085 exhibit OR's that are consistent with Phase 1 results, whereas rs7298565 exhibits an inverse OR from that of Phase 1, i.e. the minor allele of rs7298565 is associated with decreased AD risk in Phase 1 and increased AD risk in Phase 2).

ISSN: 1750-1326