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Table 2 B cell-related genes with significantly changed expression in PBL of PD-patients

From: Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease

Symbol GenBank Accession No Gene Name B cells involvement
A. Genes involved in B cell receptor signaling pathway  
BLNK NM_013314 B-cell linker B cell receptor signaling pathway (a); B cell activation (b), (g); B cell differentiation (b)
CD19 NM_001770 CD19 antigen B cell receptor signaling pathway (a); Expressed in B-cell (f), (g)
CD22 NM_001771 CD22 antigen B cell receptor signaling pathway (a); Expressed in B-cell (f), (g)
CD72 NM_001782 CD72 antigen B cell receptor signaling pathway (a); Expressed in B-cell (g)
CD79A NM_001783 CD79A antigen (immunoglobulin-associated alpha) B cell receptor signaling pathway (a),(b); B cell differentiation (b); B cell proliferation (b); B cell receptor complex (c)
CD79B NM_000626 CD79B antigen (immunoglobulin-associated beta) B cell receptor signaling pathway (a),(b); B cell receptor complex (c)
CR2 NM_001006658 complement component (3d/epstein barr virus) receptor 2 B cell receptor signaling pathway (a); B Lymphocyte Cell Surface Molecules (d)
RASGRP3 NM_170672 ras guanyl releasing protein 3 (calcium and dag-regulated) B cell receptor signaling pathway (a)
B. Genes involved in other B cell-related annotations  
BANK1 NM_017935 B-cell scaffold protein with ankyrin repeats 1 B cell activation (b)
CD40 NM_001250 CD40 antigen (tnf receptor superfamily member 5) Positive regulation of B cell activation (b); Positive regulation of B cell proliferation (b); B cell mediated immunity (b)
EBF1 NM_024007 early b-cell factor B Cell Development (e)
FCER2 NM_002002 FC fragment of ige, low affinity ii, receptor for (cd23a) Expressed in B-cell (f), (g)
IFNG NM_000619 interferon, gamma Positive regulation of B cell activation (b); B cell mediated immunity (b)
IGHD BC021276 immunoglobulin heavy constant delta Expressed in primary B-Cells (f)
IGHM BC001872 immunoglobulin heavy constant mu Positive regulation of B cell proliferation B cell receptor signaling pathway (b); B cell receptor complex (c); B Cell Development; B cell activation (e); Expressed in primary B-Cells (f)
IL1R2 NM_004633 interleukin 1 receptor, type ii Expressed in B-cell (f)
MSC NM_005098 musculin (activated b-cell factor-1) Expressed in B-cell (f)
SPIB NM_003121 spi-b transcription factor (spi-1/pu.1 related) Expressed in B-cell (f)
TCL1A NM_021966 T-cell leukemia/lymphoma 1a Expressed in B-cell (f)
C. Additional B cell-related genes  
CD180 NM_005582 CD180 antigen Expressed mainly on mature B cells (h); May be involved in the life/death decision of B-cells (j)
CRISP3 NM_006061 cysteine-rich secretory protein 3 Specifically expressed in pre-B cell [50] (i)
FAM129C NM_173544 B-cell novel protein 1 Specifically expressed in B-lymphocytes (k)
FCRL1 NM_052938 FC receptor-like 1 May serve as an activating coreceptor on B cells [51] (i)
FCRL2 NM_030764 FC receptor-like 2 Expression is limited to the mature B-cell lines (h); May have an regulatory role in normal and neoplastic B cell development (j)
FCRLA NM_032738 FC receptor-like and mucin-like 1 Specifically expressed in B-cells(k)
NFE2L3 NM_004289 nuclear factor (erythroid-derived 2)-like 3 Highly expressed in B-cell (h)
MCOLN2 NM_153259 mucolipin 2 Might play a role in B cell lysosomal function [25] (i)
NT5E NM_002526 5'-nucleotidase, ecto (CD73) Mediates B cell adhesion [52] (i)
PAX5 NM_016734 paired box gene 5 (b-cell lineage specific activator) Key regulator of the B-cell-restricted expression of the CD23a isoforms [53] (i)
TBK1 NM_013254 tank-binding kinase 1 TBK1-mediated signaling in haematopoietic cells was critical for the induction of antigen-specific B and CD4(+) T cells [54] (i)
  1. Involvement in B cells was determined based on: (a) KEGG pathway; (b) GO Biological Process; (c) GO Cellular Component; (d) Biocarta; (e) BBID; (f) UniProt Tissue database; (g) UniProt Keywords database; (h) UniProt Tissue Specificity; (i) GENERIF_SUMMARY (PubMed); (j) UniProt Function; (k) GeneCards.