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Table 1 Baseline data in the patients with MCI, AD and the controls (Assay targets were in CSF)

From: Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease

Measured variables Controls (n = 27) MCI (n = 44) AD (n = 32)
Age (years) 55.6 ± 10.0 71.9 ± 7.1b 71.4 ± 7.4b
Sex (M/F) 17/10 23/21 11/21
MMSE at baseline (0-30 p) 28.7 ± 1.1 26.2 ± 2.2b 20.1 ± 4.8a
CSF sTNFR1 (pg/mL) 705.0 ± 66.2 972.1 ± 50.7b 930.9 ± 52.5b
CSF sTNFR2 (pg/mL) 409.6 ± 130.2 602.6 ± 38.7b 832.1 ± 54.1 a
CSF TACE activity (FU/min) 53.1 ± 6.6 91.2 ± 6.6c 82.0 ± 6.8 b
  1. Values are means ± S.D., except as noted otherwise. Abbreviations: AD patients with stable cognitive functions; MCI: mild cognitive impairment; Controls, healthy controls, with unimpaired cognition after at least 3 years follow-up; MMSE, mini-mental state examination; sTNFR, soluble tumor necrosis factor-α receptor; CSF, cerebrospinal fluid.
  2. a p < 0.001 vs. Controls.
  3. b p < 0.05 vs. Controls.
  4. c p < 0.01 vs. Controls.