Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease

Table 1 Baseline data in the patients with MCI, AD and the controls (Assay targets were in CSF)

Measured variables	Controls (n = 27)	MCI (n = 44)	AD (n = 32)
Age (years)	55.6 ± 10.0	71.9 ± 7.1^b	71.4 ± 7.4^b
Sex (M/F)	17/10	23/21	11/21
MMSE at baseline (0-30 p)	28.7 ± 1.1	26.2 ± 2.2^b	20.1 ± 4.8^a
CSF sTNFR1 (pg/mL)	705.0 ± 66.2	972.1 ± 50.7^b	930.9 ± 52.5^b
CSF sTNFR2 (pg/mL)	409.6 ± 130.2	602.6 ± 38.7^b	832.1 ± 54.1 ^a
CSF TACE activity (FU/min)	53.1 ± 6.6	91.2 ± 6.6^c	82.0 ± 6.8 ^b

Values are means ± S.D., except as noted otherwise. Abbreviations: AD patients with stable cognitive functions; MCI: mild cognitive impairment; Controls, healthy controls, with unimpaired cognition after at least 3 years follow-up; MMSE, mini-mental state examination; sTNFR, soluble tumor necrosis factor-α receptor; CSF, cerebrospinal fluid.
^a p < 0.001 vs. Controls.
^b p < 0.05 vs. Controls.
^c p < 0.01 vs. Controls.

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