Figure 3
From: Dopamine and α-synuclein dysfunction in Smad3 null mice
Smad3-/- mice have fewer nigrostriatal astrocytes. In the SN the number of GFAP-ir astrocytes decreased in Smad3 deficiency (A-B, G). Illustrations depict non-activated astrocytes as verified by the labelling of thin, elongated processes in the wild-type (C) and null (D) mice. In the ST, atrophic astrocytes could be detected in Smad3 -/- null mice (F, arrow) when compared to Smad3+/+ mice (E). (H) Number of GFAP-ir cells in the striatal matrix and striosomes. The figure represents the GFAP-ir cells per mm2 in one striatal hemisphere. (I) The GFAP protein content is decreased in both the VM and ST of Smad3 null mice (Student's t-test, n = 4-6 per genotype) (J) Confocal images of Smad3 and GFAP double-labelled cells in the SN of wild-type mice showed co-localization of Smad3 in astrocytes. *P < 0.05, **P < 0.01, ***P < 0.001