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Table 1 Effects of morphine and/or HIV-1 Tat exposure ± fractalkine on the percentage of microglia in mixed-glia cultures from striata of Cx3cr1-/- (Cx3cr1GFP/GFP) mice (‡).

From: Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death

 

Control

Morphine

Tat

Morphine + Tat

Microglia (%)

(Cx3cr1 -/- mixed glia)

31.0 ± 6.7§

26.7 ± 2. 5

26.7 ± 5.1

34.9 ± 1.6

Microglia (%)

(Cx3cr1 -/- mixed glia + fractalkine)

25.8 ± 2.3

25.8 ± 6.7

25.5 ± 4.0

30.9 ± 0.7

  1. ‡ No significant effects of morphine and/or HIV-1 Tat ± fractalkine (1 μg/ml) exposure on the proportion of GFP+ microglia were noted; effects were compared using 2-way ANOVA.
  2. § The proportion of microglia in mixed glial cultures from Cx3cr1-/- mice was much greater than percentages seen in equivalent striatal cultures from wild-type mice (e.g., 8.8 ± 0.6% Iba-1+ microglia in control cultures) determined as part of another study [60].
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Molecular Neurodegeneration

ISSN: 1750-1326