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Table 1 Do Amyloid precursors "chaperone" Aβ?

From: Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

Protein Transgene
suppresses
Knock-out
accelerates
Cytotoxic inhibition In vitrointeraction In Human AD brains
Transthyretin + + + + +
Bri2 + N.D. N.D. + +
Cystatin C + N.D. N.D. + +
Gelsolin +* N.D. N.D. + +
Neuroserpin +** N.D. + + +
  1. N.D., Not Determined.
  2. *Gelsolin only expressed in livers of transgenic animals.
  3. **Neuroserpin experiments have only been done in transgenic drosophila.