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Table 1 Do Amyloid precursors "chaperone" Aβ?

From: Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

Protein

Transgene

suppresses

Knock-out

accelerates

Cytotoxic inhibition

In vitrointeraction

In Human AD brains

Transthyretin

+

+

+

+

+

Bri2

+

N.D.

N.D.

+

+

Cystatin C

+

N.D.

N.D.

+

+

Gelsolin

+*

N.D.

N.D.

+

+

Neuroserpin

+**

N.D.

+

+

+

  1. N.D., Not Determined.
  2. *Gelsolin only expressed in livers of transgenic animals.
  3. **Neuroserpin experiments have only been done in transgenic drosophila.
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Molecular Neurodegeneration

ISSN: 1750-1326