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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

Figure 3

APP overexpressing mice show increased levels of Thr668 P-APP: Brain sections from Ntg, APP, and PS/APP mice were immunostained using monoclonal 6E10 antibody and polyclonal Thr668 specific P-APP antibody. A: Representative sections from Ntg (top row), APP (middle row), and PS/APP (bottom row) mice stained with a 6E10 antibody (left column), Thr668 P-APP antibody (middle column) and composite image (right column) with Hoechst showing nuclear staining. Magnification: 40×. B: Quantification of the intensity of 6E10 and P-APP staining in Ntg, APP, PS/APP and PS mouse brains. Both APP and PS/APP mice showed significantly higher levels of APP and Thr668 P-APP with more intensity in mice expressing both PS and APP transgenes compared to APP alone. The Ntg and PS expressing mice showed low levels of APP and P-APP.

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Molecular Neurodegeneration

ISSN: 1750-1326