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Figure 2 | Molecular Neurodegeneration

Figure 2

From: The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Figure 2

Malformation of BACE1-/- OB glomeruli. Coronal sections of OBs from 60 day-old OMP-GFP; BACE1+/+ (A-D) and OMP-GFP; BACE1-/- (E-H) mice were immunostained with anti-BACE1 antibody and imaged for BACE1 (red; A, E), GFP (green; B, F), and DAPI for periglomerular cell nuclei (blue; C, G) by laser scanning confocal microscopy. Three-color image merges are shown in (D, H). Robust GFP fluorescence is observed in OSN axons and terminals in glomeruli (B, F). Note significant BACE1 co-localization with GFP in OSN terminals in BACE1+/+ glomeruli (D). Importantly, abrogation of BACE1 expression results in markedly deformed BACE1-/- glomeruli (F, H) as compared to BACE1+/+ (B, D). Scale bar in (H) = 100 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326