Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

Table 3 Effect of curcumin treatment on striatal transcripts

Transcript	Control-treated			Curcumin-treated			Treatment effect in KIs
	WT	KI	Percent change from WT	WT	KI	Percent change from WT	Percent rescue from control-treated KI levels
D1 receptor	1.13 ± 0.13	0.64 ± 0.04*	-43.4	1.1 ± 0.04	0.8 ± 0.03^‡	-27.4	+25
D2 receptor	1.31 ± 0.12	0.73 ± 0.04**	-44.1	1.07 ± 0.05	0.84 ± 0.04*	-22.1	+14
CB1 receptor	0.93 ± 0.13	0.48 ± 0.07*	-48.5	1.03 ± 0.09	0.61 ± 0.05	-40.9	+26.7
DARPP-32	1.28 ± 0.1	0.61 ± 0.03**	-52.1	1.09 ± 0.06	0.79 ± 0.04**^‡	-27.4	+29.5
Enkephalin	1.06 ± 0.06	0.55 ± 0.04**	-47.7	0.98 ± 0.06	0.56 ± 0.04**	-43.0	+1.5
Substance P	0.95 ± 0.06	0.99 ± 0.07	+5.1	0.91 ± 0.09	0.95 ± 0.09	+4.7	-4.2

WT n = 8 per group, KI n = 7 per group. * p < 0.05, ** p < 0.01 compared to control-treated WT (comparisons to WT curcumin not shown, for clarity). ^‡ p < 0.05 compared to control-treated KI. Raw data were compared using completely randomized ANOVA followed by Bonferroni's corrected for 4 comparisons. Groups were composed of balanced mixed-gender groups. Data were processed as described previously [54].

ISSN: 1750-1326