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Table 6 Association of GSTO locus SNPs with LOAD risk in the younger LOAD series with ages between 60-80 years

From: Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

N (MAF)

rs#

Locus

Series

AD

Control

OR

95% CI

p-value

  

All

2,152 (0.35)

3,013 (0.34)

0.99

0.90-1.11

NS

  

JS

544 (0.37)

634 (0.33)

1.24

1.03-1.49

0.025

  

RS

287 (0.34)

1,423 (0.34)

0.99

0.80-1.21

NS

rs156697

GSTO2

AUT

263 (0.34)

254 (0.38)

0.88

0.67-1.15

NS

  

NCRAD

531 (0.34)

119 (0.45)

0.58

0.41-0.82

0.002

  

NW

165 (0.33)

428 (0.30)

1.01

0.75-1.37

NS

  

PS

362 (0.37)

155 (0.36)

0.99

0.71-1.37

NS

  

All

2,148 (0.32)

3,011 (0.31)

1.00

0.90-1.11

NS

  

JS

544 (0.33)

644 (0.29)

1.16

0.96-1.40

0.119

  

RS

289 (0.30)

1,414 (0.31)

0.95

0.77-1.17

NS

rs4925

GSTO1

AUT

265 (0.29)

254 (0.34)

0.85

0.64-1.12

0.248

  

NCRAD

522 (0.31)

117 (0.31)

0.86

0.6-1.24

NS

  

NW

158 (0.31)

423 (0.29)

0.94

0.69-1.29

NS

  

PS

370 (0.35)

159 (0.34)

0.94

0.67-1.31

NS

  1. Results of multivariate logistic regression analysis are shown for each SNP, each series individually and for the combined series. N = number of subjects, MAF = minor allele frequency, OR = odds ratio; NS = not significant.