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Table 8 Association of GSTO locus SNPs with PD risk

From: Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

N (MAF)

rs#

Locus

Series

PD

Control

OR

95% CI

p-value

  

PD-All

661 (0.35)

702 (0.36)

0.94

0.80-1.11

NS

rs156697

GSTO1

PD-SPO

411 (0.36)

702 (0.36)

1.03

0.85-1.24

NS

  

PD FAM

250 (0.31)

702 (0.36)

0.83

0.66-1.05

0.116

  

PD-All

667 (0.30)

707 (0.33)

0.92

0.78-1.09

NS

rs4925

GSTO1

PD-SPO

416 (0.33)

707 (0.33)

1.03

0.85-1.25

NS

  

PD FAM

251 (0.27)

707 (0.33)

0.78

0.61-0.98

0.034

  1. Results of multivariate logistic regression analysis are shown for each SNP, each series individually and for the combined series. N = number of subjects, MAF = minor allele frequency, OR = odds ratio; NS = not significant.
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Molecular Neurodegeneration

ISSN: 1750-1326