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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Figure 3

13 C 6 -leucine brain apoE labeling in the presence of increased LDLR levels. (A) Wildtype and LDLR transgenic mice (3.5 months old) were labeled with 13 C6-leucine and the brains isolated after predetermined time points. ApoE was then immunoprecipitated from the cortex and the labeled/unlabeled ratios calculated via LC-MS. The labeled/unlabeled ratios were then plotted versus time for each genotype. (B) To calculate the FCR, the natural log of the labeled/unlabeled ratios were plotted over time and the monoexponential slopes were calculated (n = 5 mice per time point, error bars represent SEM, dotted lines represent 95% confidence band).

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Molecular Neurodegeneration

ISSN: 1750-1326