Figure 3

Levels of p3-Alc _α , Aβ40, and Aβ42, and Aβ42/40 ratios in CSF of Cohort 1 (Japan) following subgrouping into “low Aβ42” and “high” Aβ42” subpopulations. Subjects of Japanese cohort (Cohort 1) were divided into two subpopulations with a cut-off value of Aβ42 (500 pg/mL). (A-D, low Aβ42 subgroup). Control (Aβ42 >500 pg/mL) and MCI and AD subjects (Aβ42 < 500 pg/mL) were analyzed for p3-Alc_α (A), Aβ40 (B), Aβ42 (C) and Aβ42/40 ratio (D). (E-H, high Aβ42 subgroup). Control (Aβ42 <500 pg/mL) and MCI and AD subjects (Aβ42 > 500 pg/mL) were analyzed for p3-Alc_α (E), Aβ40 (F), Aβ42 (G) and Aβ42/40 ratio (H). Dashed line on panels C and G indicates the cut-off value of Aβ42 (500 pg/mL). Statistical analysis was performed using the Dunn's multiple comparisons test following the Kruskal-Wallis test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.