Inhibiting γ-secretase does not rescue the memory deficit of FDD
mice. a. FDDKI and WT mice were cannulated. Four weeks after cannulation mice were subjected to a NOR test. Untreated WT and FDDKI mice spent the same amount of time exploring the two identical objects on day 1. b. WT mice spent more time exploring the novel object 24 hours later, showing normal object recognition (discriminatory ratio=0.63), while FDDKI mice present amnesia and do not distinguish the new object from the old one (discriminatory ratio=0.5). c. A week after the first NOR, mice were injected in the lateral ventricle with 1μl of PBS/3μM compound-E. Injections were performed 1 hr prior to the training section, which shows that both treated groups explore equally the two identical objects. d. The following day, 1 hr before testing mice were injected in the lateral ventricle with 1μl of PBS/3μM compound-E. The GSI neither rescued the memory deficit of FDDKI mice nor it changed memory of WT animals.