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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Figure 5

Loss of LRRK2 causes age-dependent bi-phasic alterations of protein carbonyls. There is no significant difference in the levels of protein carbonyls, determined using OxyBlots, in both RIPA buffer-soluble and -insoluble fractions of kidneys between LRRK2-/- mice and wild-type (+/+) controls at one month of age. But the level of protein carbonyls is significantly reduced in the RIPA buffer-insoluble fractions of LRRK2-/- kidneys at 7 months of age compared with wild-type controls. By 20 months of age, the level of protein carbonyls is significantly increased in both RIPA buffer-soluble and -insoluble fractions of LRRK2-/- kidneys. ns, not significant; **, P < 0.01.

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