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Table 1 Normal gait in LRRK2 KO mice .Mouse gait dynamics were obtained using a motorized treadmill by ventral plane videography and analyzed with DigiGait® software

From: LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Average gait dynamics in WT, HET & KO mice
treading at a speed of 24cm/sec
Parameter WT (n=9) HET (n=8) KO (n=8) p
Stride length (cm) 6.42 ± 0.57 6.38 ± 0.71 6.09 ± 0.50 ns
Stride frequency (steps/sec) 3.84 ± 0.37 3.88 ± 0.46 4.06 ± 0.32 ns
Stride duration (sec) 0.267 ± 0.023 0.265 ± 0.029 0.254 ± 0.020 ns
 % Stance duration 58.5% ± 3.3% 59.5% ± 5.5% 59.1% ± 4.4% ns
 % Swing duration 41.5% ± 6.2% 40.5% ± 6.0% 41% ± 3.9% ns
Step angle (deg) 61.1 ± 9.6 64.3 ± 6.5 59.1 ± 6.8 ns
Fore paw angle (deg) 9.63 ± 1.68 11.76 ± 5.04 12.51 ± 4.13 ns
Hind paw angle (deg) 18.97 ± 3.13 20.08 ± 1.81 18.43 ± 2.42 ns
Total steps (No./paw) 17 ± 5 18 ± 4 18 ± 4 ns
Hind limb shared stance (sec) 0.047 ± 0.026 0.050 ± 0.018 0.036 ± 0.013 ns
  1. Values are means ± StdDev and were analyzed by one-way ANOVA; ns = p>0.05.
  2. Gate indices were not different between WT, HET and KO mice. Data are plotted as mean ± SD and were analyzed by ANOVA.