Table 1 Normal gait in LRRK2 KO mice .Mouse gait dynamics were obtained using a motorized treadmill by ventral plane videography and analyzed with DigiGait® software
Average gait dynamics in WT, HET & KO mice | ||||
|---|---|---|---|---|
treading at a speed of 24cm/sec | ||||
Parameter | WT (n=9) | HET (n=8) | KO (n=8) | p |
Stride length (cm) | 6.42 ± 0.57 | 6.38 ± 0.71 | 6.09 ± 0.50 | ns |
Stride frequency (steps/sec) | 3.84 ± 0.37 | 3.88 ± 0.46 | 4.06 ± 0.32 | ns |
Stride duration (sec) | 0.267 ± 0.023 | 0.265 ± 0.029 | 0.254 ± 0.020 | ns |
% Stance duration | 58.5% ± 3.3% | 59.5% ± 5.5% | 59.1% ± 4.4% | ns |
% Swing duration | 41.5% ± 6.2% | 40.5% ± 6.0% | 41% ± 3.9% | ns |
Step angle (deg) | 61.1 ± 9.6 | 64.3 ± 6.5 | 59.1 ± 6.8 | ns |
Fore paw angle (deg) | 9.63 ± 1.68 | 11.76 ± 5.04 | 12.51 ± 4.13 | ns |
Hind paw angle (deg) | 18.97 ± 3.13 | 20.08 ± 1.81 | 18.43 ± 2.42 | ns |
Total steps (No./paw) | 17 ± 5 | 18 ± 4 | 18 ± 4 | ns |
Hind limb shared stance (sec) | 0.047 ± 0.026 | 0.050 ± 0.018 | 0.036 ± 0.013 | ns |