Table 2 List of parameter values for Model 2

k _prod

Aβ production rate

1.86e-5 molecules s^-1

Value from Mawuenyega at al. 2010 [22]

k _deg

Aβ degradation rate

2.10e-5 s^-1

Values from Mawuenyega et al. 2010 [22]

k _dimer

Aβ dimerisation rate

1.2e-7 molecules^-1 s^-1

Chosen from global parameter scan

k _dedimer

Dissociation rate of dimers

8.5e-6 s^-1

Chosen from global parameter scan

k _pf

Formation rate of plaques

2.8e-6 molecules^-1 s^-1

Value in range of 1 new aggregate per 5 days (Lomakin et al., 1997) [13]

k _pg

Maximum rate of plaque growth

5.7e-3 s^-1

Approx 5 monomers per min (Lomakin et al. 1997) [13]

k _pghalf

Size of plaque at which growth rate is half of k _pg

4.0 molecules

Chosen from global parameter scan

k _disagg

Rate of plaque disaggregation

5.4e-5 s^-1

Chosen from global parameter scan

k _degNep

Neprilysin degradation rate

0.0 s^-1

Normal rate (neprilysin remains constant with age)

1.8e-10 s^-1

Set so that neprilysin declines to about 700 by age 60 years.