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Table 1 Potential NURR1-interacting sequence motifs residing in the 5' upstream flanking region of the Top IIβ promoter

From: Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons

Location

Sequence

Orientation

From -174 to -167

TGACgTTT

R

From -720 to -713

AAAGGTCt

F

From -1570 to -1563

cAAGGTCA

F

From -1752 to -1745

TGACtTTT

R

From -2369 to -2362

AAAtGTCA

F

From -3197 to -3190

cAAGGTCA

F

From -4401 to -4394

TtACCTTT

R

From -4444 to -4437

TGACCTTa

R

From -4508 to -4501

aGACCTTT

R

From -6190 to -6183

AAAGGTCA

F

From -7586 to -7579

AAAtGTCA

F

From -9890 to -9883

TGACCTTg

R

  1. The 5' flanking sequences were searched for the presence of NURR1-binding sequence motifs. Thirteen sequence motifs were identified to have no more than one base deviation from the consensus NBRE within the 10 kb upstream region. The deviated base is shown in lower case. The orientation (R: reverse, F: forward) and location relative to the transcription start site of each motif are shown.