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Figure 1 | Molecular Neurodegeneration

Figure 1

From: IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

Figure 1

Generation and characterization of brain IκBα conditional knockout (cKO) mice. (A) Breeding scheme used for generating the IκBα cKO mice and the littermate controls (Ctrl). (B) Real-time quantitative PCR (qPCR) analysis of IκBα mRNA (N = 3/genotype) and (C) Western blot analysis of IκBα protein levels in brain lysates of 2–3 month old adult cKO and Ctrl hippocampal tissue. (D) Representative images of Nissl-stained brain sections of 10–12 month old Ctrl and cKO mice. Scale bar: 1 mm. White boxes highlight the sampling region for counting pyramidal neuronal number. (E) Quantification of pyramidal neurons in hippocampal CA1 region (N = 5/genotype) and (F) brain weight measurements of Ctrl and IκBα cKO mice (N = 9-14/genotype).

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Molecular Neurodegeneration

ISSN: 1750-1326