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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Figure 3

Gene Set Enrichment analysis of disregulated transcripts . Gene Set Enrichment analysis was performed using the Molecular Signature Database “motif-based” to search for known and likely regulatory elements present in the promoters and 3’ UTR on our entire group of 38 affected genes. Shadow boxes represent positive hits for the regulatory proteins on the top row for each tested gene in the first column with a p<0.001. FOXF2: forkhead box F2; FOXO3A: forkhead box O3A; IPF1: Insulin promoter factor 1; REST: RE1-silencing transcription factor; PIT1: POU domain, class1, transcription factor 1 (Pit1) and ARNT: aryl hydrocarbon receptor nuclear translocator.

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Molecular Neurodegeneration

ISSN: 1750-1326