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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

Figure 1

Electrocorticogram recording and histological changes associated with epileptic seizures in X11-/-/X11L-/-mice. (A) An electrocorticogram recorded in 13-week-old X11-/-/X11L-/- mice (n = 4). Epileptic discharges are underlined. (B) c-Fos (a, b, c) and Egr-1/zif268 (d, e, f) immunoreactivity in the hippocampus of X11+/+/X11L+/+ (a, d) and X11-/-/X11L-/- (b, c, e, f) mice under steady-state conditions (a, b, d, e) and at 90 min after an epileptic episode (c, f). Scale bar, 200 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326