Skip to main content
Figure 3 | Molecular Neurodegeneration

Figure 3

From: Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons

Figure 3

Therapeutic utility of IGF-I. A, IGF-I (100 nM) treatment for 24 hours stimulates frataxin in human astrocytes (n=3, independent experiments). B, One month of treatment of YG8R mice (4–6 months-old) with subcutaneous IGF-I (Alzet minipumps, 50 μg/kg/day) resulted in normalization of motor coordination in the rota-rod (F=10.1; n= 8–30). No effects on body weight were observed in treated mice. *p<0.05.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326