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Figure 5 | Molecular Neurodegeneration

Figure 5

From: BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

Figure 5

Traumatic brain injury contributes to Aβ deposition by activating BACE1 transcription. Traumatic brain injury activates BACE1 by inducing oxidative stress and by activating the NF-κB transcription factor. This leads to Aβ deposition. Aβ, amyloid peptide; AGE, advanced glycation end products; BACE1, β-secretase βAPP cleaving enzyme 1; NF-κB, nuclear factor-κB.

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Molecular Neurodegeneration

ISSN: 1750-1326