accumulation causes paralysis . Age-related paralysis phenotype in Aß3-42 and Aß1-42 expressing C. elegans. Adults shifted to either 20°C or 25°C from the first day of adulthood (day zero) onwards. Plotted are the mean fractions of individuals not paralyzed ± 95% confidence intervals. Shown are control strain CL2122 (20°C n = 60; 25°C n = 60), Aβ3-42 expressing CL2120 (20°C n = 56; 25°C n = 60), and Aβ1-42 expressing GMC101 (20°C n = 58; 25°C n = 0), where n = number of individuals assayed. Plot shown is representative of 4 experiments.