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Figure 1 | Molecular Neurodegeneration

Figure 1

From: The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

Figure 1

APP/Aβ pathology in the hippocampus of TgCRND8 mutant APP and Dutch mutant APP transgenic mice. Aβ and APP species were visualized using the 6E10 antibody. Extracellular amyloid plaques (asterisk) are evident in (B) TgCRND8 APP transgenic mice (3.5 months old), while (C) Dutch mutant APP (17 months old) exhibit intracellular APP/Aβ-like immunoreactivity (APP/Aβ-LIR; arrow). No APP/Aβ-LIR is seen when 6E10 is used to immunostain brain of a wild type mouse (A). Inset panels represent higher magnification of 6E10 immunoreactivity of plaques in TgCRND8 mutant APP mice and intracellular APP/Aβ-LIR in Dutch mutant APP mice. Scale bars represent 500 μm. Scale bars in insets represent 100 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326