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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

Figure 3

EVP-0015962 selectively affects processing of Aβ isoforms. A and B. Effect of EVP-0015962 treatment on production of Aβ isoforms, measured by MALDI-TOF mass spectrometry. Mass spectra from H4-APP751 cells treated with DMSO (A) and 700 nM EVP-0015962 (B). It should be noted that a relative quantification cannot be interpreted as a direct reflection of an absolute or relative abundance of a species since the ionization efficiency and hydrophobicity might be different for different Aβ isoforms. N = 1 experiment.

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Molecular Neurodegeneration

ISSN: 1750-1326