Table 1 Mean (± sem) percent of control after chronic of treatment with EVP-0015962 at 20 or 60 mg/kg/day
Neocortex | Hippocampus | |||||
|---|---|---|---|---|---|---|
Stain and pathology | Control | EVP-0015962 (mg/kg/day) | Control | EVP-0015962 (mg/kg/day) | ||
Parameter | diet | 20 | 60 | diet | 20 | 60 |
6E10 immunostaining of Aβ plaque pathology | ||||||
Percent area | 100 (10.8) | 69.2 (9.7) | 65.3 (16.3) | 100 (10.8) | 62.1 (13.2)* | 53.1 (15.2)* |
Number/mm2 | 100 (7.9) | 65.2 (8.8) | 71.3 (15.0) | 100 (9.7) | 61.0 (12.2)* | 53.9 (16.8)* |
Size (μm2) | 100 (6.5) | 105.5 (8.8) | 88.5 (5.4) | 100 (16.4) | 99.4 (15.7) | 104.1 (11.6) |
ThioflavinS staining of Aβ plaque pathology | ||||||
Percent area | 100 (18.0) | 64.3 (14.3) | 29.9 (7.3)* | 100 (14.7) | 40.7 (16.9)** | 27.3 (6.5)** |
Number/mm2 | 100 (12.4) | 64.3 (8.0) | 59.6 (14.1) | 100 (12.7) | 55.2 (15.6)* | 50.7 (12.8)* |
Size (μm2) | 100 (8.5) | 87.8 (12.2) | 58.1 (10.6)* | 100 (6.8) | 56.5 (16.3) | 58.9 (27.0) |
GFAP immunostaining of reactive astrocytes | ||||||
Percent area | 100 (12.5) | 95.8 (14.5) | 61.6 (7.6) | 100 (9.0) | 95.8 (7.7) | 87.2 (9.7) |
CD11b immunostaining of activated microglia | ||||||
Percent area | 100 (12.8) | 86.3 (5.0) | 66.2 (7.7) | 100 (12.1) | 69.8 (9.2) | 61.8 (10.7) |