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  • Lecture presentation
  • Open Access

Identifying an APP-binding protein in neuronal cell death

  • 1 and
  • 2
Molecular Neurodegeneration20127 (Suppl 1) :L22

https://doi.org/10.1186/1750-1326-7-S1-L22

  • Published:

Keywords

  • Neuronal Cell Death
  • Solute Carrier Family
  • Reactive Oxygen Species Release
  • Essential Cellular Process
  • Rodent Stroke

Background

Apoptosis is an essential cellular process involved in multiple diseases and a major pathway for neuronal death in neurodegeneration. The detailed signaling events/pathways that lead to apoptosis, especially in neurons, require further elucidation.

Results

Here we find that a mitochondrial solute carrier family protein, appoptosin, induces reactive oxygen species release and intrinsic caspase-dependent apoptosis. The physiological function of appoptosin is to transport/exchange glycine/5-amino-levulinic acid across the mitochondrial membrane for heme synthesis. Alzheimer’s β-amyloid precursor protein interacts with appoptosin and modulates appoptosin-induced apoptosis. Levels of appoptosin are upregulated in brain samples from Alzheimer’s disease and infarct patients and in rodent stroke models, as well as in cells treated with β-amyloid (Aβ) and glutamate. Downregulation of appoptosin prevents the cell death and caspase activation caused by glutamate or Aβ insults.

Conclusion

Our study identifies appoptosin as a crucial player in apoptosis and a novel proapoptotic protein involved in neuronal cell death, providing a possible new therapeutic target for neurodegenerative disorders and cancers.

Authors’ Affiliations

(1)
Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian, 361005, China
(2)
Neurodegenerative Disease Research Program, Sanford-Burnham Medical Research Institute, La Jolla, California, USA

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