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Molecular Neurodegeneration

Open Access

Dynamic neuronal regulatory network during the progression of Alzheimer’s disease suggests an adaptive survival strategy

  • Jiya Sun1, 2,
  • Xuemei Feng1,
  • Dapeng Liang1, 2,
  • Yong Duan3, 4 and
  • Hongxing Lei1, 3
Contributed equally
Molecular Neurodegeneration20127(Suppl 1):O3

Published: 7 February 2012

Alzheimer’s disease (AD) is the most common neurodegenerative disease. In this work, comprehensive analyses on transcriptome studies of human postmortem brain tissues from AD patients revealed stepwise breakdown of the cellular machinery during the progression of AD at semi-quantitative level. At the early stage of AD, the accumulation of A-beta oligomers and amyloid plaques leads to the down-regulation of biosynthesis and energy metabolism, likely a response to the reduced level of nutrient and oxygen supply. At the intermediate stage, the progression of the disease leads to enhanced signal transduction, also likely an adjustment to the deteriorating environment. The late stage is characterized by the elevated apoptosis due to the excessive regulatory and repair burden. Interestingly, the elevated apoptosis at the late stage is accompanied by elevated anti-apoptotic signals, suggesting an adaptive survival strategy even at the late stage of AD. These findings can serve as theoretical basis for pharmaceutical intervention of Alzheimer’s disease.


Authors’ Affiliations

Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Graduate University, Chinese Academy of Sciences, Beijing, China
UC Davis Genome Center and Department of Applied Science, One Shields Avenue, Davis, USA
College of Physics, Huazhong University of Science and Technology, Wuhan, China


© Sun et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.