Skip to main content
Figure 2 | Molecular Neurodegeneration

Figure 2

From: Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Figure 2

Overexpression of muVAPB, but not wtVAPB, causes aggregation. (A) Lumbar spinal cord sections from different transgenic lines (NTG, wtVAPB, muVAPB35, and muVAPB35/60) were stained with VAPB antibody. VAPB-positive inclusions were found throughout the whole spinal cord in the muVAPB mice but not in the wtVAPB mice. The inserts show high magnification of the boxed areas in the large image. Aggregates are indicated by arrows. Scale bars: 30 μm. (B) Motor neurons in muVAPB mice, but not in wtVAPB mice, show VAPB aggregates. The neurons were marked by staining for neurofilaments high molecular weight subunit (NF-H). The VAPB aggregates are indicated by arrows in the figure. Scale bars: 10 μm.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326