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Figure 7 | Molecular Neurodegeneration

Figure 7

From: Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Figure 7

muVAPB did not cause structural change for ER and mitochondria or induce UPR response. (A) ER and mitochondrial morphology in the motor neurons from the lumbar spinal cords of muVAPB35/60 mice at 18-month old were not different from the NTG controls. (Abbreviations: Mit-mitochodria, Lf-lipofuscin, Nuc-nucleus, ER-endoplasmic reticulum.) Scale bars: 5 μm. (B) Relative ratios of Chop and BiP mRNA from the spinal cords of muVAPB35 mice at the age of 14 months as determined by RT-PCR and compared to the age-matched NTG mice. All values are represented by mean±SD. No significant difference was detected.

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Molecular Neurodegeneration

ISSN: 1750-1326