Figure 4

Normal spatial reference memory in BRI2-Aβ mice. Spatial reference memory was tested in two cohorts of mice. First cohort (panels A-C) underwent a battery of non-mnemonic test (Figure 3) and was tested in spatial reference memory WM test at the age of 15.3 months. A separate cohort of experimentally naïve mice (panels D-F) was tested at the age of 17 months. (A) Search path, (B) average swim speed and (C) search bias for the platform location in the target quadrant (TQ) during the probe trial carried out at the end of training for 15.3 month-old mice. Panels D, E, and F represent search path, swim speed and search of TQ, respectively for naïve 17 month-old mice. S1 - S5 represent daily training sessions. The dashed lines (panels C and F) represent a chance level performance. Error bars represent s.e.m. * p < 0.001 indicates the comparison of each genotype against 25% chance level performance.