Normal cognition in transgenic BRI2-Aβ mice

Table 1 The analysis of the genotype effect in behavioral tests

	Test/behavior	Age	F	df_tr,df_er	sig	ω²
Study 1	FC/exploration	12mo	0.9	3,64	0.44	0.00
	FC/context memory		1.0	3,64	0.41	0.00
	FC/pre-CS		0.7	3,64	0.53	0.00
	FC/CS tone memory		1.7	3,64	0.18	0.02
Study 2	OF/anxiety index	14.2mo	0.7	2,21	0.51	0.00
	OF/latency to explore		0.3	2,21	0.92	0.00
	OF/path length		1.3	2,21	0.30	0.00
	OF/path tortuosity		1.7	2,21	0.20	0.00
	OF/object exploration		1.2	2.21	0.82	0.00
	RR/latency to fall	14.6mo	2.1	2,20	0.19	0.00
	VPWM/path	15.1mo	0.9	2,21	0.42	0.00
	VPWM/speed		0.4	2,21	0.79	0.00
	VPWM/path tortuosity		2.3	2,21	0.12	0.09
	SRWM/search path	15.3mo	0.1	2,21	0.95	0.00
	SRWM/swim speed		2.6	2,21	0.10	0.06
	SRWM/%path in TQ		0.2	2,21	0.81	0.00
	*SRWM/search path	*17mo	0.4	1,19	0.53	0.00
	*SRWM/swim speed		0.4	1,19	0.52	0.00
	*SRWM/%path in TQ		0.3	1,19	0.86	0.00
	CTA/D2	15.8	1.0	2,20	0.40	0.00
	CTA/D10-D15		1.0	2,20	0.40	0.03

The ANOVA results pertain only to the differences between non-Tg, BRI2-Aβ1-40, BRI2-Aβ1-42, and BRI2-Aβ1-40/Aβ1-42 mice in Study 1, and the differences between non-Tg, BRI2-Aβ1-40, BRI2-Aβ1-42 mice in Study 2. Other significant main effects of sex, repeated testing, and their interactions, as well as comparisons against chance performance are reported in the text. In Study 1 12mo-old mice were tested in a fear conditioning (FC) test. In Study 2 the mice were tested in a battery of tests including open-field (OF), rotarod (RR), visible (VP) and spatial reference (SR) memory of the water maze (WM) tests, and conditioned taste aversion (CTA) tests following longitudinal experimental design. Results indicated by * pertain to the SRWM test carried out on a cohorts of naïve 17 mo-old non-Tg and BRI2-Aβ1-42 mice. ω² represents the effect size due to the genotype of mice.

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