Figure 9
From: Conformational templating of α-synuclein aggregates in neuronal-glial cultures
Three-dimensional differences in morphology of αS inclusions. Confocal Z slice analysis midway through the pSer129+ αS aggregates (green) show that (A) M83-like inclusions derived from rAAV2/1-mediated overexpression of human A53T αS and addition of A53T-derived human αS fibrils have a diffuse distribution throughout the cell body. In contrast, (B) M47-like inclusions derived from rAA2/1-mediated overexpression of human E46K αS and addition of E46K-derived human αS fibrils show rounded, punctate staining. Bar scale = 10 μm.