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Table 1 Association analysis of TREM2 variant c.140G>A (rs75932628; p.R47H) in disease

From: TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

Disorder (n) Patient, n(%) Control, n(%) OR (95% CI) p-valuea
Controls (1324)    6 (0.45)    
FTD (609) 13 (2.1) 6 (0.45) 5.064 (1.9, 13.51) 0.0012
ALS (765) 5 (0.7) 6 (0.45) 1.466 (0.43, 4.94) 0.5378
PD (683) 9 (1.3) 6 (0.45) 3.144 (1.1, 9.03) 0.0333
PSP (722) 5 (0.6) 6 (0.45) 1.537 (0.41, 5.78) 0.5249
Ischemic Stroke (448) 3 (0.7) 6 (0.45) 1.506 (0.37, 6.17) 0.5689
  1. a Uncorrected p-values are shown. The association in FTD would remain significant after a conservative Bonferroni correction for multiple testing (significance level p<0.01).