Figure 8

I/R injury induced changes in retinal gene expression. After normalizing to control eyes, changes of gene expression ratios in I/R-injured eyes were plotted based on log₂ fold change values through 8 time points (0, 6 hr, 1, 3, 7, 14, 21 and 28 days) after I/R injury. Time dependent changes in gene expression for three signaling pathways are shown. Among various genes, changes of 12 genes were plotted based on their functional aspects such as signaling pathway related with (A) cell death/protection, (B) function as a molecular chaperone, and (C) inflammation.