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Figure 7 | Molecular Neurodegeneration

Figure 7

From: S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease

Figure 7

Increased S-nitrosylation of parkin and p53 levels in a mouse model of PD. Levels of S-nitrosylated parkin (SNO-parkin), total parkin, p53, and actin were examined by biotin-switch and western blot in mice treated with the nNOS inhibitor 3-Br-7-NI, PQ/MB, or PQ/MB with 3-Br-7-NI (left panel). Ratios of SNO-parkin and total parkin were quantified to indicate the extent of parkin S-nitrosylation under the indicated conditions (center panel). Quantifications of p53 signal were normalized to actin (right panel). Values are mean + SEM, n = 3 mice per condition; * p < 0.05.

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Molecular Neurodegeneration

ISSN: 1750-1326