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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex

Figure 2

Nicotine increased the excitability of PFC layer I GABAergic interneurons. A, Representative spikes elicited by a depolarizing current pulse in the absence (control) or presence of nicotine (5 μM) recorded in a PFC layer I GABAergic interneuron. Scale bars: 50mV, 100ms. B, Bar plot summary of the percentage increase of firing rate by nicotine in layer I interneurons in the absence or presence the antagonist MEC (10 μM) or MLA (1 μM). Note that the effect of nicotine was calculated in two different groups based on the change of resting potential (ΔRm) by nicotine. *: p < 0.05, ANOVA.

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Molecular Neurodegeneration

ISSN: 1750-1326