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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex

Figure 3

Aβ diminished the nicotinic effect on sIPSC in PFC layer V pyramidal neurons. A-C, Representative sIPSC traces (A) and cumulative plots of the distribution of sIPSC amplitude (B) and frequency (C) in the absence (control) or presence of nicotine (5 μM) recorded in a PFC pyramidal neuron pre-incubated with Aβ oligomer (1 μM, 3 hours). Scale bars (A): 100pA, 15s. D, Bar plot summary of the percentage change of sIPSC amplitude and frequency by nicotine in PFC pyramidal neurons with or without Aβ pretreatment. *: p < 0.05, **: p < 0.01, t-test.

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Molecular Neurodegeneration

ISSN: 1750-1326