Drosophila melanogaster as a model organism for Alzheimer’s disease

Table 2 Overview of performed large-scale screens for modifiers of toxicity induced by expression of AD-linked genes in Drosophila melanogaster

Transgene causing a REP	Screened library	Results	Reference
hTau[V337M]	2,276 EP strains	• Kinases, phosphatases (CDK5, GSK3β, PAR1)	Shulman & Feany [69]
		• Apoptosis
		• Novel: Ataxin 2, Fmr1
hTau[V337M]	1,250 P-element strains	• Cytoskeletal components	Blard et al.[70]
		• Molecular chaperones
		• Chromatin remodelling
hTau[WT]	920 P-lethal strains	• Kinases, Phosphatases	Ambegaokar et al.[71]
	895 EY strains	• Autophagy/lysosomal
		• RNA processing
		• Chromatin regulation
		• Cytoskeletal
GMR > Aβ42	1,963 EP strains	• Secretory pathway	Cao et al.[72]
		• Cholesterol homeostasis
		• Chromatin regulation
Pan neural Arctic Aβ42 life span reduction	3,000 de novo insertions of transposable elements	• Fenton chemistry and oxidative stress are involved in AD pathology	Rival et al. [61]
Pan neural Arctic Aβ42 life span reduction	3,000 de novo insertions of transposable elements	• Ferritin expression protects from β-amyloid toxicity	Rival et al. [61]

The table lists only screens in which the fly was used as primary screening tool. Not listed are screens using other sources to gain candidates, later confirmed in flies.

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