Figure 3
Immunohistochemical staining pattern of Aβ 5-X in cortex of sporadic AD human brain. Vascular Aβ5-x immunoreactivity (A, E, F) was detected in the majority of the SAD cases analyzed in hippocampus (A) and cerebral cortex (E), whereas extracellular Aβ5-x-positive deposits (C, G, H) were less abundant in both brain areas (C, D). The pan-Aβ antibody 24311 (B, D) demonstrates cerebral amyloid angiopathy (CAA) and plaque load (arrows). The same cortical region stained in a parallel section with the AB5-3 antibody (F, H) binds preferentially to blood vessels presenting CAA and barely recognizes plaques. Scale bar: 50 μm.