Figure 4
Immunohistochemical staining pattern of Aβ 5-x in cortex of familial AD human brain. Vascular and parenchymal Aβ5-x-positive deposits were detected in parallel sections obtained from FAD cases including subjects with the Arctic (A) and Swedish mutations (C) in contrast to abundant 4G8-immuoreactivity in both cases (B, D). Sections of a PS1∆E9 mutation carrier probed with the AB5-3 antibody (E) showed equal or higher vascular Aβ5-x-immunoreactivity compared to Aβ42 (F) whereas the Aβ5-x-parenchymal deposits were detected with lower intensity. Scale bar: 200 μm.