Abundance of Aβ5-xlike immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

Table 2 Transgenic AD-like mouse models in which Aβ _5-x deposition has been analyzed

Mouse model	AβPP	PS1	Tau	Promoter	Age	Aβ_5-xplaques	Ref.	Affected regions
APP/PS1KI	Swe, Lon	M233T, L235P	-	Thy1 (APP) PS1 knock-in	10 m	++	[20]	C, Hip, Th, PiC
5XFAD	Swe, Flo, Lon	M146L, L286V	-	Thy1 (APP, PS1)	12 m	++	[21]	C, Hip, Th, PiC
3xTg	Swe	M146V	P301L	Thy1 (APP, Tau) PS1 knock-in	18 m	+	[19]	Hip

Abbreviations: Swe Swedish, Flo Florida, Lon London, m age in months, C Cortex, Hip hippocampus, Th thalamus, PiC piriform cortex.

ISSN: 1750-1326