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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice

Figure 2

Temporal changes of specific optic nerve gene clusters related to neuronal loss and regeneration failure. Neuron specific and axonal regeneration related neuronal clusters were selected from the optic nerve GO tables and the microarray ratios of the genes within each of these clusters graphed temporally (0 to 28 days post crush (dpc)). Neuronal clusters identified included (A) positive regulation of axonogenesis, (B) regulation of synaptic plasticity, (C) neuron projection, (D) synaptic transmission, and (E) neurofilament cytoskeleton organization. Significance of these clusters was determined using the Benjamini multiple test correction, GO enrichment score χ2 test and Fishers Exact test (p < 0.05).

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