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Figure 2 | Molecular Neurodegeneration

Figure 2

From: U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

Figure 2

Immunohistochemistry of U1 snRNPs in FAD and Down syndrome. DAB immunohistochemistry staining of postmortem human frontal cortex (50 μm free floating sections) from control, PS1 mutation carrier, APP mutation carrier, and Down syndrome patient with (A- D) U1-70k, (E- H) Sm-D1, and (I- L) U1-A. Black arrows designate U1 snRNP tangle-like aggregates. (M- P) PHF and (Q- T) β-amyloid provided as reference for other AD pathologies. Representative sections shown. Scale bar = 10 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326