The top ten most up-regulated genes at each age, in cortex and hippocampus, illustrate the alteration of inflammatory and immune processes from M4 onwards. Venn diagrams representing the top ten up-regulated genes in cortex (A) and hippocampus (B) of 5XFAD mice at M1 (blue), M4 (yellow), M6 (green) and M9 (red). Genes are listed by rank of fold change, the cut-off for analysis being FC > 1.5 when comparing gene probe signals from 5XFAD with wild type mice. Note that only Ttr dysregulation is present at both M1 and M4 in the cortex while the other 9 genes are specific to M1. However, at M4, M6 and M9, 60% and 40% of these genes are consistently dysregulated in the cortex and the hippocampus, respectively.