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Table 3 Upregulated genes, fold changes, and associated functional categories for genes consistently dysregulated from M4 to M9

From: Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

   Cortex Hippocampus  
Gene Probe M1 M4 M6 M9 M1 M4 M6 M9  
Gusb A51P211491 0.9 2.5 3.2 3.2 1.1 3.0 3.6 3.9 Lysosomal biogenesis
Naglu A52P504361 1.0 2.1 2.1 2.2 0.8 1.7 2.2 2.0
Hexa A51P282667 1.1 1.9 2.0 2.3 1.2 1.7 2.3 2.4
Hexb A51P453111 1.0 2.5 2.0 3.2 0.9 2.8 2.0 3.3
Ctsd A65P13209 1.1 3.0 4.4 2.4 0.9 2.8 3.8 3.1
Tgfb1 A51P390715 1.1 1.8 1.7 2.3 0.8 2.3 2.6 1.6 TGF-β signaling
Tgfbr1 A51P2137206 1.1 1.5 1.7 1.7 0.8 1.6 1.4 1.9
Tgfbr2 A51P450573 1.0 1.9 2.1 2.3 1.0 2.2 2.0 3.7
Aif1 A51P400543 1.0 2.1 2.4 2.2 1.0 2.5 2.3 2.9 Markers of microglial activation
Ptprc A55P1990324 1.0 2.0 1.7 2.0 1.0 2.0 2.1 2.5
Cd86 A55P1971951 0.9 1.8 2.3 2.5 1.1 2.5 3.0 3.5
Cd14 A51P172853 1.0 2.7 3.2 3.8 1.0 2.6 3.6 3.3
Igf1 A55P2031631 0.9 2.6 2.0 5.1 1.0 3.0 3.0 4.2 Protective activities
Osmr A51P319460 0.9 1.6 2.7 3.1 0.7 2.5 3.0 5.3
Grn A51P192800 0.9 2.5 2.3 2.6 1.1 2.2 3.0 2.5
  1. Fold changes are indicated in bold when FC > 1.5.