Table 3 Upregulated genes, fold changes, and associated functional categories for genes consistently dysregulated from M4 to M9

Gusb

A51P211491

0.9

2.5

3.2

3.2

1.1

3.0

3.6

3.9

Lysosomal biogenesis

Naglu

A52P504361

1.0

2.1

2.1

2.2

0.8

1.7

2.2

2.0

Hexa

A51P282667

1.1

1.9

2.0

2.3

1.2

1.7

2.3

2.4

Hexb

A51P453111

1.0

2.5

2.0

3.2

0.9

2.8

2.0

3.3

Ctsd

A65P13209

1.1

3.0

4.4

2.4

0.9

2.8

3.8

3.1

Tgfb1

A51P390715

1.1

1.8

1.7

2.3

0.8

2.3

2.6

1.6

TGF-β signaling

Tgfbr1

A51P2137206

1.1

1.5

1.7

1.7

0.8

1.6

1.4

1.9

Tgfbr2

A51P450573

1.0

1.9

2.1

2.3

1.0

2.2

2.0

3.7

Aif1

A51P400543

1.0

2.1

2.4

2.2

1.0

2.5

2.3

2.9

Markers of microglial activation

Ptprc

A55P1990324

1.0

2.0

1.7

2.0

1.0

2.0

2.1

2.5

Cd86

A55P1971951

0.9

1.8

2.3

2.5

1.1

2.5

3.0

3.5

Cd14

A51P172853

1.0

2.7

3.2

3.8

1.0

2.6

3.6

3.3

Igf1

A55P2031631

0.9

2.6

2.0

5.1

1.0

3.0

3.0

4.2

Protective activities

Osmr

A51P319460

0.9

1.6

2.7

3.1

0.7

2.5

3.0

5.3

Grn

A51P192800

0.9

2.5

2.3

2.6

1.1

2.2

3.0

2.5