Figure 4

500 mkd Thiamet-G may reduce sarkosyl-insoluble tau in the TAPP mice. Levels of sarkosyl-insoluble tau were assessed by Western blot analysis in both the 0 and 500 mkd Thiamet-G treated TAPP mice groups and indicated a strong trend towards less sarkosyl-insoluble tau in the 500 mkd group. Error bars represent standard error of the mean (± S.E.M) and p-values result from a student’s unpaired one-tailed t-test. N =18 (Control) and n =17 (500 mkd Thiamet-G).