Figure 6
From: Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
Forced treadmill exercise does not affect neuronal cell counts in the spinal cord and brain. A) Spinal cord motor neuron counts were not significantly different across all groups. B) Transgenic mice displayed significant neurodegeneration in the cortex compared to non-transgenic controls. C) Transgenic mice displayed significant neurodegeneration in the CA3 of the hippocampus compared to non-transgenic controls. D) Transgenic mice displayed significant neurodegeneration in the CA1 of the hippocampus compared to non-transgenic controls. E) Representative images of the spinal cord and cortex. Scale bars represent 50 μm for spinal cord and 100 μm for the cortex. F) Representative images of the CA1 and CA3 subregions of the hippocampus. Scale bar represents 25 μm. [NTg-SED (n = 6), NTg-EX (n = 8), Tg-SED (n = 6), Tg-EX (n = 8)]; (*) denotes a significant difference (p < 0.05). A two-way ANOVA with the Tukey’s HSD post-hoc was used to detect statistically significant differences.